The study complies with the current ethical guidelines, and has been approved by the Azienda Ospedaliero-Universitaria Consorziale Policlinico of Bari (Bari, Italy). The written informed consent was.

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Finally, Ethiopians are known to have high altitude adaptations. This could be due to long term residence in the region, or, assimilation of favorable alleles from the long term residents by later.

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Alzheimer’s Disease. The 4 allele confers increased susceptibility to development of AD, but is neither necessary nor sufficient to cause AD. The presence of one 4 allele increases the risk of developing AD two-to-threefold, while having two 4 alleles increases the risk to 15-fold or higher in Caucasian populations.

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And finally, it can refer to non-linear fitness effects due to combinations of alleles across loci. In this case we’ve already seen how variation on the molecular level of gene expression due to.

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